Scientist, Analytical Development and Quality Control, Brisbane

Company Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Nurix Therapeutics seeks an experienced Scientist to join the Analytical Development and Quality Control group. The Scientist will conduct analytical method development and material characterization studies to inform drug substance and drug product development. They will also provide operational oversight at external CDMO/CTL partners, manage reference standards and impurity markers, collaborate in CMC risk management, and author technical reports.

This position is onsite at Nurix headquarters in Brisbane, CA.

Key Responsibilities

Characterization and development studies at our internal laboratory: 2D‑LC for impurity profiling of complex samples, derisking HPLC test procedures, and adaptation of incompatible methods to mass spectrometry

Structural elucidation by high‑resolution Orbitrap Tribrid Mass Spectrometry

QbD HPLC method development using multivariate DOE software

Forced degradation and elucidation of degradation mechanisms

Accelerated predictive stability studies and modeling of packaging configurations and long‑term stability

Authorship of technical documents such as analytical development reports, stability reports, and storage statements

Management of reference standards and impurity markers

Manage and organize documentation and data

Contribute to protocol development and oversight/troubleshooting of method transfers

Liaise with Medicinal Chemistry, Bioanalytical, DMPK, and Preclinical departments

Compliance with cGMP quality standards and internal SOPs

Travel up to 5%

Required Qualifications

Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field). BS with 10+ years, MS degree with 6+ years, or PhD with up to 4 years of relevant experience

Expertise in operation and maintenance of mass spectrometers

Experience in HPLC operation and method development

Ability to critically interpret data and articulate technical concepts in cross‑functional teams

Ability to ensure assigned activities are completed to the satisfaction of project timelines

Strong interpersonal skills that foster collaboration within and outside of the organization

Bonus Qualifications

Experience with accurate mass instrumentation such as Orbitrap Tribrid mass spectrometers

Experience in operation of 2D‑LC

Experience in the determination of structures of small molecule impurities and/or metabolites

Experience protein and/or ADC characterization by mass spectrometry

Familiarity with gas chromatography, NMR, particle size analysis, solid state characterization, dissolution, ICP‑MS/OES, and/or FTIR

Experience with reference standard management, stability programs, and/or method validation

Familiarity with ICH guidelines, cGMPs, and pharmacopeial chapters

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative

Solutions and results‑oriented focus

Hands‑on approach; resourceful and open to diverse points of view

Salary Range Scientist I: $123,841–$144,272

Scientist II: $143,260–$161,064

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

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